In a large pot, cook pasta in boiling water for 6 minutes. Drain and set aside.
In a medium bowl combine pasta sauce, tomato sauce, oregano, salt, and pepper. Stir to combine. Set aside.
Spray your slow cooker with nonstick spray. Add one cup of the sauce mixture to the bottom, add half the penne on top. Sprinkle half the pepperoni and half the sausage over the penne. Top with half of the mozzarella cheese and then 1 cup of sauce mixture.
Repeat layers – remaining penne, pepperoni & sausage, handful of mozzarella (you should have about another handful left for the top), and remaining sauce. Top with remaining cheese.
Cover and cook on high for 3 hours, or low for 4-5 hours or until heated through. When time is up, stir the pizza pasta to evenly coat with sauce and cheese.