Preheat oven to 375°F. Grease a 9x13 inch casserole dish with cooking spray.
Cut each Pillsbury Refrigerated Biscuit into quarters (4 pieces). Spread on the bottom of the casserole dish.
Pour pasta sauce on top of biscuits and gently toss to coat.
Spread frozen meatballs evenly on top of pasta sauce. Sprinkle evenly with cheese and Italian seasoning.
Bake 40 to 45 minutes. The cheese will be completely melted, meatballs cooked and it will be bubbly and hot. Let it cool for a few minutes before serving. Store any leftovers in the fridge.